Our solution to infertility
Why testing your uterine receptivity immune analysis?
You will find below a table of birth rates following the application of the therapeutical recommendations proposed by MatriceLab Innove. The results were obtained from a cohort of 1741 women who had failed to implant their embryos in IVF or had repeated miscarriages.
Among these women we found a deregulation of the immune environment in 81.5% of cases. The second table compares the results of the patients with immune overactivation who made an attempt directly after their result with those with immune overactivation who, before making a new attempt, checked the effectiveness of the treatment (by carrying out a biopsy with the proposed treatment). For the latter, depending on the results of this second biopsy, the treatment could be modified.
Deregulation of the immune environment
Patients with immune over-activation
Who is MatriceLab for?
“The tissue that spontaneously leaves at the time of menstruation, the endometrium, is collected to analyze the local immunological balance at the key moment when the uterus is preparing for a possible implantation. The endometrial biopsy is performed by your reproductive doctor in consultation. After a vaginal ultrasound, a suction pipette is inserted into the uterus (Cornier pipette). Once the pipette is inside the uterus, the suction rod is activated and a small back and forth movement is made in the endometrium to suck it out. The biopsy lasts about 1 minute and may cause pain similar to menstruation. Rest assured, the pain does not last. We accompany doctors to give them the best advice to perform this biopsy without pain.”
Dr Nathalie Ledee
Samples and documents must be sent to the MatriceLab Innove laboratory by mail in the envelopes provided or by specialized carrier for patients with cured hepatitis. We recommend a quick shipment so that the biopsy arrives within 48 hours. We recommend that you avoid sending the biopsy on weekends or the day before a weekend and that you keep the sample (in its packaging) in the refrigerator.
Your results will be sent to you by mail within 3 weeks (delays may be extended in case of closure of the laboratory or due to the health crisis: info on our facebook page) from the date of receipt of the biopsy. Your doctor will also receive a more detailed report with recommendations for the treatment to be implemented for your next attempt. We invite you to contact your doctor if you have any questions regarding the interpretation of your work-up and the proposed treatment strategy.
The MatriceLab kit contains
Une réponse à vos questions
It is a sampling of the endometrial lining. Using a Cornier pipette, the gynecologist will take a sample of your endometrium and place it in two separate tubes. This quick procedure can be painful in the moment, so we encourage you to discuss it with your doctor beforehand.
We do not perform the biopsy in our laboratory. You must schedule an appointment with your gynecologist. The necessary biopsy materials are sent to your doctor upon their request via email. If your gynecologist does not wish to perform this exam, we can direct you to other gynecologists near you.
The biopsy should be performed during the implantation window (which begins after the embryo transfer window). The date of the biopsy must be scheduled with the doctor who will perform the sampling because it is fully dependent on your cycle.
We recommend performing the biopsy in a substituted cycle regardless of your cycle’s regularity. The biopsy will be performed after at least 10 days of estrogen alone and 7 days of estrogen and progesterone (or between 5.5 and 10 days after the start of progesterone). Your gynecologist will prescribe the treatment for you. Estrogens are to be started on the first day of the cycle (first day of the period). For those without a cycle, your doctor may prescribe you to take the pill for one month (in order to recreate a cycle) and then start the estrogens on the first day of the period.
The biopsy can also be performed in a natural cycle 5 to 9 days after ovulation, that is, 7 to 11 days after the LH peak or 8 to 12 days after ovitrelle injection. It is important to monitor the cycle to be sure of the correct phase of the cycle, either by measuring progesterone levels 48 hours before the biopsy, or by measuring the LH peak, or by the date of ovitrelle injection. These details will need to be communicated on the report to be included with the biopsy.
If the biopsy is not performed according to the recommendations defined above, the analysis cannot be done. Therefore, we recommend performing the biopsy in a substituted cycle because nearly 3% of biopsies performed in a natural cycle cannot be analyzed because the biopsy was not done in the implantation window, which forces patients to repeat the biopsy.
It is not possible to drop off a sample at the laboratory as access is restricted to personnel and carriers.
The shipment must be made by post or specialized carriers (in the case of patients who have been cured of hepatitis B).
Please return the envelope as soon as possible (provide rapid shipping for biopsies taken outside of mainland France) so that the sample reaches us within 48 hours.
Avoid sending it on a Friday or the eve of a public holiday. You can keep the biopsy in the refrigerator while waiting for shipment.
The “MatriceLAB Innove” envelope must contain:
The box containing the small tube with the biopsy in its plastic bag
The signed consent form
The “MatriceLAB Innove” receptivity report
The prescription signed by your doctor
A copy of serology results from less than one year ago.
You will receive your results by mail within 3 weeks from the date of receipt of the biopsy, provided that payment has been made. This deadline is extended during Christmas, Easter and August holidays (information in the News section). A copy of this report with any therapeutic recommendations will be sent to your doctor. We advise you to contact your doctor for interpretation of the results and implementation of proposed therapeutic strategies.
In some cases (<5%), it may happen that we cannot provide you with results because either:
- the quantity of the sample is insufficient
the biopsy is degraded (RNA degradation) due to too long transportation time,
- improper packaging, etc.
- the biopsy was performed in the wrong phase of the cycle (proliferative or late secretory phase)
In this case, the analyses will not be invoiced. You will need to make a new appointment with your doctor to perform a new biopsy after a complete cycle has passed. This new biopsy cannot be done the following month: there must be two months between the first and second biopsy to avoid the effect of the first biopsy influencing the results of the second.