Une réponse à vos questions

This is addressed in particular to:

• Women presenting with repeated and unexplained implantation failures after several attempts at IVF/ICSI.
• Women with several unexplained miscarriages
  Couples who wish to use a donation of oocytes and would like to ensure beforehand that they are properly receptive in order to optimise attempts
• Women with unexplained infertility

This test can nevertheless be performed on any woman who would like to confirm that she has no problem with uterine receptivity, even at the start of a PMA course

It is a sample of the endometrial mucosal membrane. Using a Cornier pipette, the gynaecologist takes a sample of your endometrium. He will put it in two separate tubes. This very rapid procedure can nevertheless be painful at the time it is taken. We encourage you to talk with your doctor about it beforehand.

This date should be set with the physician who will take this sample, because it fully depends upon your cycle.

We recommend performing the biopsy on a mock cycle with estrogen and progesterone intake. Your gynaecologist can prescribe this treatment. Oestrogens are to be started on the first day of the cycle (first day of menstruation). For those who do not have a cycle, your physician can prescribe that you take the pill for one month (in order to re-create a cycle), then to start oestrogens on the first day of menstruation. The patient need at least 10 days of estrogen alone before introducing the progesterone. The biopsy should be done one week after the introduction of the progesterone (but could be realised between 5.5 to 10 days of progesterone).

The biopsy could also be performed on a natural cycle or with simple stimulation (FSH), between 5 and 9 days after ovulation (or 7 to 11 days after the LH surge or 8 to 12 days fater the ovitrelle injection) while monitoring the luteal phase by dosing the progesterone (> 10mg / ml 48 hours before the biopsy). In the event of a biopsy performed on a natural cycle, please inform us in case your period arrives within less than 4 days after the biopsy.

We recommend, however, that the biopsy should be done in a mock cycle whatever the regularity of your cycle. In fact, nearly 3% of biopsies performed during a natural cycle cannot be tested, because the biopsy was not performed during an implantation window; patients are then requested to have a new biopsy taken.

If the biopsy was not realised as recommended above, the uterine receptivity test cannot be performed. In this case, tests are not invoiced but you should set another appointment with your physician to schedule another biopsy.

Upon simple request (email), we send kits with the material needed for 2 to 10 patients to the physician (we do not send these to the patient).

These kits contain, for each patient:

• A tube of RNA Later (stabiliser and preservative for RNA)
  Packaging to send these samples
• An information sheet (to be filled in by the patient and physician) about fertility issue antecedents
• A consent form to be signed by the physician and the patient

A copy of the serology results for HIV, hepatitis B and C, dated less than one year before the biopsy, with signature of the laboratory physician, must be provided with the biopsy. For regulatory reasons, we can only test samples which have negative serology results (or on patients immunised for hepatitis B). Without a valid copy of these results, we cannot perform the tests (screen shots of the medical file or printed results sent electronically are not accepted).

Must one have specific documents or material to perform a test?

The kits are sent on Wednesdays by colissimo. The requests made Monday or Tuesday are fulfilled by sending during that week. Requests made on the following days are sent Wednesday of the following week.

These kits are sent free-of-charge to the physician. The shipping costs are included in the biopsy charges which are paid by the patient.

These kits can be stored for many months at room temperature.

• The box containing the small tube with the biopsy in a plastic bag
• The signed consent form The “MatriceLAB Innove” receptivity test
• The order signed by your physician
• A copy of the serology results which are not older than one year

In some cases (less than 5%), we cannot perform the tests because:

• the quantity of the sample is too low
• the biopsy has deteriorated (deterioration of the RNA) due to a transport period which was too long, or improper packaging, etc.
• the biopsy is performed at the wrong phase of the cycle (proliferative phase or late secretory phase)

In this case, tests are not invoiced. Only the histological dating is billed (if not paid by health insurance). In this case, you should set a new appointment with your physician to re-do a biopsy after completing the next cycle. This new biopsy can only be done the month after. There is therefore a two-month gap between the first and second biopsy to avoid the first biopsy affecting the second.